Hepbest - blueberry pharmaceuticals
Descripition :
- Hepbest tablets are required to prevent for HIV-1 infections, now it is also indicated in the condition like hepatitis B viral infection Tenofovir Alafenamide is an active most predominant component which is present in Hepbest tablet.
- An ideal activity of Hepbest tablet is; Anti-HIV or Anti-retroviral activity Anti-hepaciviral activity Hepbest is not a curable medicine; it may prevent transmission of virus to others and reduce the exposure
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Hepbest Tablet |
Hepbest working As :
Tenofovir is phosphorylated into tenofovir diphosphate intracellularly using cellular kinase enzyme. The pharmacologically active metabolite tenofovir diphosphate is expels anti-hepaciviral activity by obstructing hepatitis B viral multiplication through infusion of this metabolite by reverse transcriptase enzyme into viral DNA
SIDE EFFECTS :
SERIOUS ADVERSE EFFECTS
Risk of severe acute worsening of hepatitis B viral infection Aggression of renal impairment Lactic acidosis or hepatomegaly with steatosis
COMMON SIDE EFFECTS
Headache, Fatigue, Abdominal pain, Nausea, Back pain, Cough, Glycosuria, Pancreatitis, Amylase and lipase elevation
HEPBEST INTERACTED WITH SOME DRUGS LIKE :
- Tenofovir Alafenamide is a P-gp& BCRP transporter substrate, while concurrent usage of Hepbest with P-gp or BCRP strong inhibitors causes alteration in absorption of tenofovir Alafenamide
- P-gp or BCRP inducers decreases the effect of concentration of tenofovir Alafenamide which leads to reduce the healing effect of tenofovir Alafenamide
- Moderate inhibitor of P-gp or BCRP with Hepbest tablet causes increasing the concentration of tenofovir Alafenamide
- Hepbest combined with drugs which reduce the renal functions causes increasing the concentration of tenofovir Alafenamide. This is because tenofovir is highly eliminated through kidney
- Hepbest with anti-convulsants like phenytoin, Phenobarbital, or carbamazepine causes decreasing the tenofovir Alafenamide concentration
- Tenofovir Alafenamide interacts with anti mycobacterials agents causes decreasing the effect of concentration of TAF
- Hepbest with st Johns wort causes decreasing the therapeutic effect of tenofovir Alafenamide
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